In a study investigating a Mediterranean diet in relation to prostate cancer progression in men under active surveillance, researchers from the University of Texas MD The Anderson Cancer Center found that men with localized prostate cancer who had a Basic food patterns reported that they corresponded better to the basic principles of a Mediterranean diet, performed better in the course of their illness

“Men with prostate cancer are motivated to find a way to influence the progression of their disease and improve their quality of life,” said Justin Gregg, MD., Assistant Professor of Urology and lead author of the study published today in Cancer, “A Mediterranean diet is non-invasive, good for general health, and, as this study shows, has the potential to affect the progression of your cancer”

After adjusting for factors known to increase the risk of the cancer getting worse over time, such as age, prostate specific antigen (PSA), and tumor volume, men on a diet high in fruits, vegetables, Legumes, grains, and fish all contained a reduced risk of their prostate cancer growing or progressing to a point where many would consider active treatment.The researchers also looked at the effects of diabetes and statin use and found similar risk reductions in these patient populations

The study, of which the largest number of participants were white, also found that the effects of a Mediterranean diet were more pronounced in African-American participants and others who identified themselves as non-white Men, who also have a higher risk of prostate cancer death and disease progression, are more than 50% higher

“The Mediterranean Diet Has Been Consistently Linked to Lower Risk of Cancer, Cardiovascular Disease and Mortality This study in men with early prostate cancer brings us to provide evidence-based dietary recommendations to optimize outcomes in cancer patients who along with their Families have many questions in this area, one step closer, “said Carrie Daniel-MacDougall, Ph DrD., associate professor of epidemiology and lead author of the study

After skin cancer, prostate cancer is the most common cancer in men in the US because most of the cases are low-risk diseases that are localized in the prostate and have favorable results, many men do not need immediate treatment and choose to active monitoring by your doctor Prostate cancer treatments can result in changes in quality of life and deterioration in urinary and sexual function Hence there is interest in finding modifiable factors for men who are treated by active surveillance

The study tracked 410 men with an active surveillance protocol with localized Gleason Class 1 or 2 prostate cancer.All study participants were given a confirmatory biopsy at the start of the study and assessed every six months through clinical examinations and laboratory tests of serum antigen PSA and testosterone

The study participants were 829% Caucasian, 81% black and 9% other or unknown. The mean age was 64 years, 15% of the men were diabetic and 44% used statins

The men completed a 170-point questionnaire on the frequency of staple foods, and a Mediterranean nutritional value was calculated for each participant in 9 energy-adjusted food groups Participants were then divided into three groups with high, medium and low adherence to the diet

After adjusting for age and clinical characteristics, the researchers found a significant association between a high baseline diet and a lower risk of cancer progression. For every one point increase in Mediterranean diet, the researchers observed a> 10 % lower risk of progression After a mean follow-up time of 36 months, 76 men saw their cancer progressing

The study was limited by the small number of events in these mostly low-risk disease men who were monitored at MD Anderson. Future research is needed to determine if the same effects are seen in larger and more diverse patient populations and in men with higher levels of prostate cancer Risk occurring

“Our results suggest that consistent adherence to a diet high in plant-based foods, fish, and a healthy balance of monounsaturated fats can be beneficial for men diagnosed with early-stage prostate cancer,” Gregg said “We are confident that these results, coupled with additional research and future validation, will encourage patients to adopt healthy lifestyles”

This research was supported by the Department of Defense Prostate Cancer Research Program Early Career Award (W81XWH-18-1-0193), a grant in support of the National Cancer Institute Cancer Center to MD Anderson (CCSG 5P30 CA016672-37), and a study Cancer Prevention Training Award Postgraduate Integrative Epidemiology Training Program from the & Research Institute of Texas (RP160097) on Cancer Prevention

Materials provided by the University of Texas M D. Anderson Cancer Center Note: Content is editable by style and length

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Mediterranean Diet

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